Diogo Onofre Souza Selected Research

Guanosine

3/2016	Intranasal guanosine administration presents a wide therapeutic time window to reduce brain damage induced by permanent ischemia in rats.
12/2015	Guanosine Protects Against Cortical Focal Ischemia. Involvement of Inflammatory Response.
1/2014	The potential therapeutic effect of guanosine after cortical focal ischemia in rats.
10/2012	Effects of chronic guanosine treatment on hippocampal damage and cognitive impairment of rats submitted to chronic cerebral hypoperfusion.
8/2012	Protective effects of guanosine against sepsis-induced damage in rat brain and cognitive impairment.
5/2006	Amnesic effect of GMP depends on its conversion to guanosine.
8/2004	Quinolinic acid promotes seizures and decreases glutamate uptake in young rats: reversal by orally administered guanosine.
7/2003	Chronically administered guanosine is anticonvulsant, amnesic and anxiolytic in mice.
6/2002	Guanosine enhances glutamate uptake in brain cortical slices at normal and excitotoxic conditions.

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Diogo Onofre Souza Research Topics

Disease

9	Seizures (Absence Seizure) 01/2019 - 07/2003
8	Mitochondrial Diseases (Mitochondrial Disease) 05/2018 - 06/2014
6	Brain Ischemia (Cerebral Ischemia) 03/2016 - 06/2002
5	Insulin Resistance 04/2017 - 04/2010
4	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2021 - 10/2013
4	Cognitive Dysfunction 05/2019 - 01/2009
4	Inflammation (Inflammations) 08/2018 - 04/2017
4	Hyperammonemia 05/2018 - 01/2012
4	Ischemia 03/2016 - 12/2012
3	Alzheimer Disease (Alzheimer's Disease) 04/2021 - 12/2012
3	Gliosis 10/2019 - 05/2008
3	Hepatic Encephalopathy 05/2018 - 12/2015
3	Neoplasms (Cancer) 01/2017 - 07/2003
3	Machado-Joseph Disease (Spinocerebellar Ataxia Type 3) 01/2017 - 03/2011
3	Brain Injuries (Brain Injury) 01/2017 - 08/2006
3	Epilepsy (Aura) 06/2014 - 07/2003
2	Neuroinflammatory Diseases 01/2020 - 10/2018
2	Glutaric Acidemia I 10/2019 - 01/2018
2	Neuromyelitis Optica (Devic's Disease) 01/2019 - 01/2010
2	Body Weight (Weight, Body) 04/2017 - 06/2013
2	Parkinson Disease (Parkinson's Disease) 02/2011 - 02/2004
2	Status Epilepticus (Complex Partial Status Epilepticus) 01/2011 - 05/2008
2	Vascular Diseases (Vascular Disease) 10/2010 - 04/2010
2	Malnutrition (Nutritional Deficiencies) 10/2006 - 04/2005
1	Schizophrenia (Dementia Praecox) 01/2021
1	Mental Disorders (Mental Disorder) 01/2021
1	Herpes Zoster 01/2021
1	Malaria 01/2021
1	Infections 12/2020
1	Demyelinating Diseases (Demyelinating Disease) 10/2019
1	Chronic Disease (Chronic Diseases) 10/2019
1	Memory Disorders (Memory Loss) 05/2019
1	Optic Neuritis (Retrobulbar Neuritis) 01/2019
1	Myelitis 01/2019
1	Autism Spectrum Disorder 08/2018

Drug/Important Bio-Agent (IBA)

11	Glutamic Acid (Glutamate)FDA Link 01/2017 - 06/2002
9	GuanosineIBA 03/2016 - 06/2002
8	Proteins (Proteins, Gene)FDA Link 01/2018 - 04/2005
6	CytokinesIBA 12/2020 - 10/2015
5	AmmoniaIBA 05/2018 - 01/2012
5	AntioxidantsIBA 04/2017 - 01/2012
4	Neuroprotective AgentsIBA 01/2020 - 02/2004
4	Glucose (Dextrose)FDA LinkGeneric 10/2019 - 01/2013
4	ResveratrolIBA 05/2018 - 06/2014
4	Quinolinic AcidIBA 12/2011 - 07/2003
3	Glutaryl-CoA DehydrogenaseIBA 10/2019 - 01/2017
3	Biomarkers (Surrogate Marker)IBA 08/2018 - 08/2006
3	Reactive Oxygen Species (Oxygen Radicals)IBA 05/2018 - 07/2014
3	LipidsIBA 04/2017 - 04/2010
3	Heme Oxygenase-1IBA 04/2017 - 06/2014
3	Superoxide DismutaseIBA 04/2016 - 09/2007
3	CatalaseIBA 04/2016 - 09/2007
3	Insulin (Novolin)FDA Link 04/2016 - 10/2010
2	EnzymesIBA 05/2019 - 01/2017
2	Immunoglobulin G (IgG)IBA 01/2019 - 01/2010
2	Lactic Acid (Lactate)FDA LinkGeneric 01/2019 - 01/2013
2	Risperidone (Risperdal Consta)FDA LinkGeneric 10/2018 - 02/2009
2	Trans Fatty AcidsIBA 08/2018 - 04/2017
2	Glutathione (Reduced Glutathione)IBA 04/2017 - 07/2014
2	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA 01/2017 - 07/2014
2	Superoxides (Superoxide)IBA 01/2017 - 07/2014
2	NADPH Oxidases (NAD(P)H oxidase)IBA 01/2017 - 07/2014
2	NeurotoxinsIBA 02/2016 - 01/2012
2	Oxygen (Dioxygen)IBA 12/2015 - 07/2014
2	NitrogenIBA 12/2015 - 07/2014
2	Glutamate-Ammonia Ligase (Glutamine Synthetase)IBA 10/2015 - 07/2014
2	N-Methylaspartate (NMDA)IBA 06/2014 - 08/2003
2	Adenosine Triphosphatases (ATPase)IBA 06/2014 - 01/2011
2	Therapeutic UsesIBA 01/2014 - 09/2010
2	Thiobarbituric Acid Reactive SubstancesIBA 08/2012 - 09/2007
2	beta-apocarotenoid-14',13'-dioxygenase (ADO)IBA 12/2011 - 10/2010
2	Anticonvulsants (Antiepileptic Drugs)IBA 12/2011 - 08/2004
2	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 12/2011 - 08/2003
2	Phosphopyruvate Hydratase (Enolase)IBA 06/2011 - 08/2006
2	PurinesIBA 02/2011 - 05/2006
2	GuanineIBA 02/2011 - 05/2006
2	Pilocarpine (Ocusert)FDA LinkGeneric 01/2011 - 05/2008
2	Cyclosporine (Ciclosporin)FDA LinkGeneric 10/2010 - 04/2010
2	NucleotidasesIBA 10/2010 - 07/2007
2	BombesinIBA 02/2004 - 07/2003
1	Amyloid (Amyloid Fibrils)IBA 04/2021
1	VaccinesIBA 01/2021
1	Purinergic Receptors (Receptors, Purine)IBA 01/2021
1	SaponinsIBA 01/2021
1	ProteomeIBA 01/2021
1	Dextroamphetamine (Dexedrine)FDA LinkGeneric 01/2021
1	Uric Acid (Urate)IBA 01/2021
1	FlavonoidsIBA 01/2020
1	ApigeninIBA 01/2020
1	Lysine (L-Lysine)FDA Link 10/2019
1	AcidsIBA 10/2019
1	Scopolamine (Hyoscine)FDA Link 05/2019
1	GlycogenIBA 01/2019
1	AntigensIBA 01/2019
1	Deoxyglucose (2 Deoxy D glucose)IBA 01/2019
1	Adenosine Triphosphate (ATP)IBA 01/2019
1	Haloperidol (Haldol)FDA LinkGeneric 10/2018
1	MicroRNAs (MicroRNA)IBA 08/2018

Therapy/Procedure

2	Ligation 01/2018 - 08/2012
2	Traditional Medicine (Folk Remedies) 01/2017 - 12/2016